This is not about pipe smoking, but I thought it might be of interest because it's about Sherlock Holmes.
Hidden Clues, an article written by a medical doctor, discusses how Arthur Conan Doyle used his medical expertise in many of Watson's descriptions of various characters, and further makes the case that Doyle, in his many descriptions of Holmes, may have been describing the symptoms of someone with Asperger's Syndrome, some 70 years before the syndrome was diagnosed by Hans Asperger.
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